The traditional herbal formulation, <i>Jianpiyifei II</i>, reduces pulmonary inflammation induced by influenza A virus and cigarette smoke in mice

Abstract Chronic obstructive pulmonary disease (COPD) is a worldwide chronic inflammatory lung disease, and influenza A virus (IAV) infection common cause of acute exacerbations COPD (AECOPD). Therefore, targeting viral infections represents promising strategy to prevent the occurrence development flare ups in AECOPD. Jianpiyifei II (JPYFII) traditional herbal medicine used China treat patients with COPD, its clinical indications are not well understood. However, investigation anti-inflammatory effects underlying mechanism using an animal model smoking have been reported previous study by our group. In addition, some included herbs, such as Radix astragali aupleuri, were exhibit antiviral effects. aim present was investigate whether JPYFII formulation relieved inflammation clearing IAV mouse that exposed cigarette smoke experimentally. treatment during exposure significantly reduced number cells observed bronchoalveolar lavage fluid (BALF), expression proinflammatory cytokines, chemokines, superoxide production, load IAV-infected smoke-exposed mice. alone did reduce BALF or Il-6, Tnf-a, Il-1β. The results demonstrated exerted effect exacerbation (CS)-exposed mice infected IAV. Our suggested could potentially be AECOPD associated infection.